Lipotoxicity induced pancreatic beta cell damage is associated with GPR119/MST1/FoxO1 Pathway
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چکیده
منابع مشابه
Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase.
Lipid perturbations associated with triglyceride overstorage in beta-cells impair insulin secretion, a process termed lipotoxicity. To assess the role of hormone-sensitive lipase, which is expressed and enzymatically active in beta-cells, in the development of lipotoxicity, we generated transgenic mice overexpressing hormone-sensitive lipase specifically in beta-cells. Transgenic mice developed...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2021
ISSN: 1734-1922,1896-9151
DOI: 10.5114/aoms/126556